Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cells.

@article{Sakuma2004StimulationOC,
  title={Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cells.},
  author={Yoko Sakuma and Ziaodong Li and Carol C. Pilbeam and Cynthia B Alander and Daichi Chikazu and Hiroshi Kawaguchi and Lawrence G. Raisz},
  journal={Bone},
  year={2004},
  volume={34 5},
  pages={827-34}
}
Prostaglandins (PGs), particularly PGE(2), can stimulate bone resorption and formation and auto-amplify their effects by inducing cyclooxygenase (COX)-2. We examined the role of different PG receptors in stimulating cAMP production and COX-2 expression in murine calvarial osteoblasts. Cells were obtained from PGE(2) receptor (EP2R and EP4R) wild-type and knockout (KO) mice and from mice transgenic for the COX-2 promoter fused to a luciferase reporter. We analyzed effects of selective agonists… CONTINUE READING

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