Stimulation of c-Src by prolactin is independent of Jak2.

  title={Stimulation of c-Src by prolactin is independent of Jak2.},
  author={J A Fresno Vara and Marta Carretero and Hayd{\'e}e Ger{\'o}nimo and Kurt Ballmer-Hofer and Jorge Mart{\'i}n-P{\'e}rez},
  journal={The Biochemical journal},
  volume={345 Pt 1},
Interaction of prolactin (PRL) with its receptor (PRLR) leads to activation of Jak and Src family tyrosine kinases. The PRL/growth hormone/cytokine receptor family conserves a proline-rich sequence in the cytoplasmic juxtamembrane region (Box 1) required for association and subsequent activation of Jaks. In the present work, we studied the mechanisms underlying c-Src kinase activation by PRL and the role that Jak2 plays in this process. PRL addition to chicken embryo fibroblasts (CEF… CONTINUE READING

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