Stimulation of bile acid synthesis by dibutyryl cyclic AMP in isolated rat hepatocytes

Abstract

Freshly isolated rat hepatocytes were used to examine the effects of dibutyryl cyclic AMP on the incorporation of14C-acetate and14C-cholesterol into bile acids. After an initial lag period, both precursors were incorporated into cholic and chenodeoxycholic acids at a linear rate for the subsequent 60 min. An apparent stimulation of bile acid formation… (More)
DOI: 10.1007/BF02535783

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