Stimulation of benzodiazepine receptors in the dorsal hippocampus and median raphé reveals differential GABAergic control in two animal tests of anxiety.

@article{Gonzalez1998StimulationOB,
  title={Stimulation of benzodiazepine receptors in the dorsal hippocampus and median raph{\'e} reveals differential GABAergic control in two animal tests of anxiety.},
  author={Luis E. Gonzalez and Abdel Ouagazzal and Sandra E. File},
  journal={The European journal of neuroscience},
  year={1998},
  volume={10 12},
  pages={3673-80}
}
The effects of pharmacological challenges to the benzodiazepine receptors in the dorsal hippocampus and median raphé nucleus were investigated in the social interaction and the elevated plus-maze tests of anxiety in rats. In the social interaction test, bilateral administration of midazolam (1 and 2 micrograms), into the dorsal hippocampus had anxiolytic effects; flumazenil (500 ng) was silent, but was able to antagonize the anxiolytic effects of midazolam (2 micrograms). In the social… CONTINUE READING

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