Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid.

  title={Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid.},
  author={Manfred Karobath and G{\"u}nther Sperk},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={76 2},
The effect of the neurotransmitter gamma-aminobutyric acid (GABA) on high-affinity binding of benzodiazepines to brain membranes has been investigated. GABA stimulated [3H]diazepam binding by more than 100% when extensively washed membranes from brain tissue were used. This GABA-stimulated benzodiazepine binding occurred in all brain regions examined. The stimulation was specific for GABA agonist. It was inhibited by the GABA receptor blocker bicuculline methiodide. A large number of compounds… CONTINUE READING


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