Stimulation of arachidonic acid release and prostaglandin synthesis by bryostatin 1.

@article{Parker1988StimulationOA,
  title={Stimulation of arachidonic acid release and prostaglandin synthesis by bryostatin 1.},
  author={Judy Parker and Moseley Waite and George R. Pettit and Larry W. Daniel},
  journal={Carcinogenesis},
  year={1988},
  volume={9 8},
  pages={
          1471-4
        }
}
The mechanism of tumor promotion may involve stimulation of prostaglandin production. Previous studies with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) have identified two effects of TPA on prostaglandin production. TPA stimulates both arachidonic acid release and de novo synthesis of prostaglandin H synthase. Activation of protein kinase C by TPA appears to be part of the mechanism to cause arachidonic acid release. However, it is unclear if induction of prostaglandin H… Expand
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