Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat.

@article{Ji2008StimulationOA,
  title={Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat.},
  author={Xiao-hua Ji and Jin-Zhao Ji and Hui Zhang and Bao-Ming Li},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year={2008},
  volume={33 9},
  pages={2263-71}
}
Stimulation of alpha2-, especially alpha2A-adrenoceptor (AR), in the prefrontal cortex (PFC) produces a beneficial effect on cognitive functions such as working memory. Alpha2-adrenergic agonists like clonidine and guanfacine have been used experimentally and clinically for treatment of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and schizophrenia. However, the neurophysiological actions of alpha2-ARs in the PFC are poorly understood. In the present study, we… CONTINUE READING
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