Corpus ID: 46477332

Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat.

@article{Ji2008StimulationOA,
  title={Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat.},
  author={X. Ji and Jin-Zhao Ji and H. Zhang and Bao-Ming Li},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year={2008},
  volume={33 9},
  pages={
          2263-71
        }
}
  • X. Ji, Jin-Zhao Ji, +1 author Bao-Ming Li
  • Published 2008
  • Medicine
  • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
  • Stimulation of alpha2-, especially alpha2A-adrenoceptor (AR), in the prefrontal cortex (PFC) produces a beneficial effect on cognitive functions such as working memory. Alpha2-adrenergic agonists like clonidine and guanfacine have been used experimentally and clinically for treatment of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and schizophrenia. However, the neurophysiological actions of alpha2-ARs in the PFC are poorly understood. In the present study, we… CONTINUE READING