Stimulation of albumin synthesis by keto analogues of amino acids.


(1) The effect of ketoanalogues of branched-chain amino acids on albumin synthesis was examined in two biological systems using the [14C]carbonate technique. (2)alpha-Ketocaproic acid, the ketoanalogue of leucine, was able to reverse the reduced synthesis rate observed when isolated livers, from well-nourished animals were perfused with blood from rats deprived of dietary protein for 48 h. (3) A mixture of ketoanalogues of the three branched-chain amino acids, leucine, isoleucine and valine, was able to increase albumin synthesis per unit dry liver weight to above normal levels when administered intragastrically to rats 16 h after partial hepatectomy.

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@article{Kirsch1976StimulationOA, title={Stimulation of albumin synthesis by keto analogues of amino acids.}, author={Ralph E. Kirsch and L O Frith and Sommer J. Saunders}, journal={Biochimica et biophysica acta}, year={1976}, volume={442 3}, pages={437-41} }