Stimulation of airway sensory nerves by cyclosporin A and FK506 in guinea-pig isolated bronchus.

@article{Harrison1998StimulationOA,
  title={Stimulation of airway sensory nerves by cyclosporin A and FK506 in guinea-pig isolated bronchus.},
  author={Selena Harrison and Sanjay G. Reddy and Clive P Page and Domenico Spina},
  journal={British journal of pharmacology},
  year={1998},
  volume={125 7},
  pages={
          1405-12
        }
}
  • Selena Harrison, Sanjay G. Reddy, +1 author Domenico Spina
  • Published 1998
  • Chemistry, Medicine
  • British journal of pharmacology
  • We have investigated the contractile property of cyclosporin A and FK506 in guinea-pig isolated bronchus. Cyclosporin A (10 microM) failed to significantly attenuate the excitatory non-adrenergic non-cholinergic (eNANC) and cholinergic contractile response (per cent methacholine Emax) induced by electrical field stimulation (EFS). In contrast, eNANC responses were significantly attenuated by both the neurokinin (NK)-1 and (NK)-2 receptor antagonists, N-acetyl-L-tryptophan 3,5-bis… CONTINUE READING

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