Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

@article{Tontonoz1994StimulationOA,
  title={Stimulation of adipogenesis in fibroblasts by PPAR$\gamma$2, a lipid-activated transcription factor},
  author={Peter Tontonoz and Erding Hu and Bruce M Spiegelman},
  journal={Cell},
  year={1994},
  volume={79},
  pages={1147-1156}
}
Peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) is an adipocyte-specific nuclear hormone receptor that has recently been identified as a key regulator of two fat cell enhancers. Transcriptional activation by PPAR gamma 2 is potentiated by a variety of lipids and lipid-like compounds, including naturally occurring polyunsaturated fatty acids. We demonstrate here that retroviral expression of PPAR gamma 2 stimulates adipose differentiation of cultured fibroblasts. PPAR… Expand
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