Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicing

@article{Ponomareva2005StimulationOA,
  title={Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicing},
  author={Olga N. Ponomareva and H. Ma and Ramzi Dakour and Timothy D. Raabe and Ch Lai and Mendell Rimer},
  journal={Neuroscience},
  year={2005},
  volume={134},
  pages={495-503}
}

Muscle and neuronal nicotinic acetylcholine receptors. Structure, function and pathogenicity.

Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic members of the ligand-gated ion-channel superfamily, which has precursors in the prokaryotic world. They are

Muscle and neuronal nicotinic acetylcholine receptors

Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic members of the ligand‐gated ion‐channel superfamily, which has precursors in the prokaryotic world. They are

Neuregulins at the neuromuscular synapse: Past, present, and future

  • M. Rimer
  • Biology
    Journal of neuroscience research
  • 2007
TLDR
It is suggested that neuregulin signaling may have an important role to play in mediating the response of adult terminal Schwann cells to denervation and might involve novel posttranscriptional molecular mechanisms.

Schwann cell‐derived neuregulin‐2α can function as a cell‐attached activator of muscle acetylcholine receptor expression

TLDR
It is demonstrated that neuregulin‐2 (Nrg‐2) α‐ and β‐isoforms can activate acetylcholine receptor (AChR) transcription as surface‐attached ligands and raised the possibility that Schwann cell‐derived NRG‐2 could activate ErbB receptors on the synaptic sarcolemma and that this could account, at least in part, for the Nrg‐mediated regulation of AChR expression.

The Q43L mutant of neuregulin 2β is a pan-ErbB receptor antagonist.

TLDR
It is hypothesized that NRG2β/Q43L and other antagonistic ligands stimulate ErbB tyrosine phosphorylation on a set of residues distinct from that stimulated by agonists, thus suggesting a novel mechanism of Erb B receptor regulation.

Neuregulin 3 and its roles in schizophrenia risk and presentation

  • D. Avramopoulos
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2018
Neuregulins, a four‐member family of epidermal growth factor‐like signaling molecules, have been studied for over two decades. They were first implicated in schizophrenia in 2002 with the detection

The proteome survey of an electricity‐generating organ (Torpedo californica electric organ)

TLDR
This analysis identified proteins that may play a role in the higher vertebrate neuromuscular junction or other electrical synapses in Torpedo californica.

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