Stimulation of a vascular smooth muscle cell NAD(P)H oxidase by thrombin. Evidence that p47(phox) may participate in forming this oxidase in vitro and in vivo.

@article{Patterson1999StimulationOA,
  title={Stimulation of a vascular smooth muscle cell NAD(P)H oxidase by thrombin. Evidence that p47(phox) may participate in forming this oxidase in vitro and in vivo.},
  author={Charles E Patterson and Johannes Ruef and Nageswara R. Madamanchi and Patricia Barry-Lane and Zhuangli Hu and Chris Horaist and Carol A. Ballinger and Allan R. Brasier and Christoph Bode and Marschall S. Runge},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 28},
  pages={19814-22}
}
Thrombin is a potent vascular smooth muscle cell (VSMC) mitogen. Because recent evidence implicates reactive oxygen intermediates (ROI) in VSMC proliferation in general and atherogenesis in particular, we investigated whether ROI generation is necessary for thrombin-induced mitogenesis. Treatment of human aortic smooth muscle cells with thrombin increased DNA synthesis, an effect that was antagonized by diphenyleneiodonium but not by other inhibitors of cellular oxidase systems. This effect of… CONTINUE READING