Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

@article{Maelfait2008StimulationOT,
  title={Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8},
  author={Jonathan Maelfait and Elisabeth Vercammen and Sophie Janssens and Peter Schotte and Mira Haegman and Stefan Magez and Rudi Beyaert},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={1967 - 1973}
}
The cytokine interleukin (IL)-1beta is a key mediator of the inflammatory response and has been implicated in the pathophysiology of acute and chronic inflammation. IL-1beta is synthesized in response to many stimuli as an inactive pro-IL-1beta precursor protein that is further processed by caspase-1 into mature IL-1beta, which is the secreted biologically active form of the cytokine. Although stimulation of membrane-bound Toll-like receptors (TLRs) up-regulates pro-IL-1beta expression… CONTINUE READING