Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+)

@inproceedings{Sukumar2010StimulationOT,
  title={Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+)},
  author={Piruthivi Sukumar and David J Beech},
  booktitle={Biochemical and biophysical research communications},
  year={2010}
}
Lead toxicity is long-recognised but continues to be a major public health problem. Its effects are wide-ranging and include induction of hyper-anxiety states. In general it is thought to act by interfering with Ca(2+) signalling but specific targets are not clearly identified. Transient receptor potential canonical 5 (TRPC5) is a Ca(2+)-permeable ion channel that is linked positively to innate fear responses and unusual amongst ion channels in being stimulated by trivalent lanthanides, which… CONTINUE READING
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