Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7

@inproceedings{Dang2013StimulationOT,
  title={Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7},
  author={Shipeng Dang and Yongde Peng and Lei Ye and Yanan Wang and Zhongqing Qian and Yuqing Chen and Xiaojing Wang and Yunzhi Lin and Xiaomei Zhang and Xiyan Sun and Qiong Wu and Yiji Cheng and Hong Nie and Min Jin and Huanbai Xu},
  booktitle={Clinical & developmental immunology},
  year={2013}
}
In inflammatory sites, high molecular weight hyaluronan fragments are degraded into lower molecular weight hyaluronan fragments (LMW-HA) to regulate immune responses. However, the function of LMW-HA in PTC progression remains to be elucidated. In this study, we found that receptor of LMW-HA, TLR4, was aberrantly overexpressed in PTC tissues and cell line W3. Exposure of W3 cells to LMW-HA promoted cell proliferation and migration via TLR4. Knockdown of TLR4 has provided evidence that TLR4 is… CONTINUE READING

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