Stimulation of Steroid C-11β Hydroxylase Activity in Adrenal Homogenates by Cyclic 3′,5′-Adenosine Monophosphate

@article{Roberts1964StimulationOS,
  title={Stimulation of Steroid C-11β Hydroxylase Activity in Adrenal Homogenates by Cyclic 3′,5′-Adenosine Monophosphate},
  author={Sidney C. Roberts and John E. Creange and Diane D. Fowler},
  journal={Nature},
  year={1964},
  volume={203},
  pages={759-761}
}
STEROID biosynthesis in the mammalian adrenal cortex is dependent on the activity of a number of complex enzyme systems, including several hydroxylases which require NADPH as cofactor1. NADPH is continuously generated from NADP within the adrenal cortex by the action of several dehydrogenases acting on appropriate substrates2. Of the latter, glucose-6-phosphate appears to be the most important3. Haynes, Koritz and Péron4 demonstrated that adenosine-3′,5′-monophosphate (cyclic 3′,5′-AMP… CONTINUE READING
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