Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor.

@article{An2010StimulationOS,
  title={Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor.},
  author={Beum-soo An and Luz Elisa Tavera-Mendoza and Vassil Dimitrov and Xiaofeng Wang and Mario R. Calderon and Hui-jun Wang and John H. White},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 20},
  pages={4890-900}
}
Hormonal vitamin D, 1,25-dihydroxyvitamin D (1,25D), signals through the nuclear vitamin D receptor (VDR). 1,25D regulates cell proliferation and differentiation and has been identified as a cancer chemopreventive agent. FoxO proteins are transcription factors that control cell proliferation and survival. They function as tumor suppressors and are associated with longevity in several organisms. Accumulating data have revealed that 1,25D and FoxO proteins regulate similarly common target genes… CONTINUE READING

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