Stimulation of Sigma Receptors with Afobazole Blocks Activation of Microglia and Reduces Toxicity Caused by Amyloid-β25–35

  title={Stimulation of Sigma Receptors with Afobazole Blocks Activation of Microglia and Reduces Toxicity Caused by Amyloid-$\beta$25–35},
  author={Adam A Behensky and Ilya E. Yasny and A. M. Shuster and Sergei B Seredenin and Andrey V. Petrov and Javier Cuevas},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  pages={458 - 467}
  • A. Behensky, I. Yasny, J. Cuevas
  • Published 1 November 2013
  • Biology, Chemistry
  • The Journal of Pharmacology and Experimental Therapeutics
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the leading cause of senile dementia in the United States. Accumulation of amyloid-β (Aβ) and the effects of this peptide on microglial cells contribute greatly to the etiology of AD. Experiments were carried out to determine whether the pan-selective σ-receptor agonist afobazole can modulate microglial response to the cytotoxic Aβ fragment, Aβ25–35. Treatment with afobazole decreased microglial activation in response to A… 

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