Stimulation of Na+-Ca2+ exchange in cardiac sarcolemmal vesicles by proteinase pretreatment.

@article{Philipson1982StimulationON,
  title={Stimulation of Na+-Ca2+ exchange in cardiac sarcolemmal vesicles by proteinase pretreatment.},
  author={Kenneth D. Philipson and Angie Nishimoto},
  journal={The American journal of physiology},
  year={1982},
  volume={243 3},
  pages={C191-5}
}
The Na+-Ca2+ exchange activity of purified canine cardiac sarcolemmal vesicles can be strikingly stimulated if the vesicles are pretreated with a serine or thiol proteinase. The Km (Ca2+) for Na+i-dependent Ca2+ influx is reduced from 22.2 +/- 2.3 to 8.1 +/- 0.3 microM while Vmax is increased from 15.1 +/- 3.6 to 18.9 +/- 5.2 nmol Ca2+ . mg protein-1 . s-1. Na+o-dependent Ca2+ efflux is also stimulated by proteinase pretreatment although passive (Na+-independent) Ca2+ efflux from the… CONTINUE READING
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L . REINLIB , AND E . CARAFOLI . Charge movements during the Na + - Ca 2 + exchange in heart sarcolemmal vesicles

  • W. Y. CHEUNG
  • Proc . NatZ . Acad . Sci . USA
  • 1980

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