Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

@article{Frost2000StimulationON,
  title={Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.},
  author={Jeffrey A Frost and Jennifer L. Swantek and Steve Stippec and M J Yin and Richard Gaynor and Melanie H Cobb},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 26},
  pages={19693-9}
}
The p21-activated kinase (PAK1) is a serine-threonine protein kinase that is activated by binding to the Rho family small G proteins Rac and Cdc42hs. Both Rac and Cdc42hs have been shown to regulate the activity of the transcription factor NFkappaB. Here we show that expression of active Ras, Raf-1, or Rac1 in fibroblasts stimulates NFkappaB in a PAK1-dependent manner and that expression of active PAK1 can stimulate NFkappaB on its own. Similarly, in macrophages activation of NFkappaB as well… CONTINUE READING
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