Stimulation of MAPK-phosphatase 1 gene expression by glucocorticoids occurs through a tethering mechanism involving C/EBP.

@article{JohanssonHaque2008StimulationOM,
  title={Stimulation of MAPK-phosphatase 1 gene expression by glucocorticoids occurs through a tethering mechanism involving C/EBP.},
  author={Krishan Johansson-Haque and Elanchelian Palanichamy and Sam Okret},
  journal={Journal of molecular endocrinology},
  year={2008},
  volume={41 4},
  pages={239-49}
}
Glucocorticoids (GCs) are known to inhibit mitogen-activated protein kinase (MAPK) signaling. This has been suggested to involve induced expression of MAPK-phosphatase 1 (DUSP1), which dephosphorylates and inactivates MAPKs. However, the mechanism for the transcriptional activation by GCs of DUSP1 or the identification of a GC-responsive region of the gene has so far not been described. To identify GC receptor (GR) binding to the human DUSP1 promoter in vivo, we used a chromatin… CONTINUE READING

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Mitogenactivated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation

  • K Horsch, H de Wet, +6 authors PA Hulley
  • Molecular Endocrinology
  • 2007
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