Stimulation of Glucose Uptake in Muscle Cells by Prolonged Treatment with Scriptide, a Histone Deacetylase Inhibitor

@article{TakigawaImamura2003StimulationOG,
  title={Stimulation of Glucose Uptake in Muscle Cells by Prolonged Treatment with Scriptide, a Histone Deacetylase Inhibitor},
  author={H. Takigawa-Imamura and Takumi Sekine and M. Murata and K. Takayama and K. Nakazawa and J. Nakagawa},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2003},
  volume={67},
  pages={1499 - 1506}
}
Glucose incorporation is regulated mainly by GLUT4 in skeletal muscles. Here we report that treatment of L6 myotubes with scriptide, a hydroxamic acid-based histone deacetylase (HDAC) inhibitor, stimulated 2-deoxyglucose uptake. The effect appeared only after 24 hr, resulting in 2.4-fold glucose uptake at treatment day 6. Scriptide acted synergistically with insulin, indicating it stimulated a distinct pathway from the insulin signaling pathway. It was not observed in undifferentiated myoblasts… Expand
51 Citations
Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells.
Acute inhibition of protein deacetylases does not impact skeletal muscle insulin action.
Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes
The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis
Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
Overexpression of HDAC1 Induces Functional β-cell Mass
Co-location of HDAC2 and Insulin Signaling Components in the Adult Mouse Hippocampus
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 22 REFERENCES
Role of SNARE's in the GLUT4 Translocation Response to Insulin in Adipose Cells and Muscle
In vivo effects of pioglitazone on uncoupling protein-2 and -3 mRNA levels in skeletal muscle of hyperglycemic KK mice.
Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.
  • K. Suzuki, T. Kôno
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1980
Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase.
  • L. Butler, Y. Webb, +11 authors P. Marks
  • Biology, Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2001
...
1
2
3
...