Stimulation of Glucose Transport by Hypoxia: Signals and Mechanisms.

@article{Behrooz1999StimulationOG,
  title={Stimulation of Glucose Transport by Hypoxia: Signals and Mechanisms.},
  author={Alireza Behrooz and Faramarz Ismail-Beigi},
  journal={News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society},
  year={1999},
  volume={14},
  pages={
          105-110
        }
}
  • A. Behrooz, F. Ismail-Beigi
  • Published 1 June 1999
  • Biology
  • News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
Glucose transport is acutely stimulated by hypoxia through enhanced GLUT-1 and GLUT-4 glucose transporter function. GLUT-1 expression is also stimulated by hypoxia or azide. Moreover, hypoxia per se, acting through hypoxia-inducible factor 1, enhances GLUT-1 transcription. GLUT-1 is the first gene whose transcription is dually stimulated in response to hypoxia and inhibition of oxidative phosphorylation. 
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