Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins

@article{Walker2008StimulationOC,
  title={Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins},
  author={Louise Walker and Carol A Munro and Irene de Bruijn and Megan D Lenardon and Alastair McKinnon and Neil A R Gow},
  journal={PLoS Pathogens},
  year={2008},
  volume={4},
  pages={1 - 8}
}
Echinocandins are a new generation of novel antifungal agent that inhibit cell wall beta(1,3)-glucan synthesis and are normally cidal for the human pathogen Candida albicans. Treatment of C. albicans with low levels of echinocandins stimulated chitin synthase (CHS) gene expression, increased Chs activity, elevated chitin content and reduced efficacy of these drugs. Elevation of chitin synthesis was mediated via the PKC, HOG, and Ca(2+)-calcineurin signalling pathways. Stimulation of Chs2p and… CONTINUE READING
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