Stimulation of B10.BR T cells with superantigenic staphylococcal toxins.

  title={Stimulation of B10.BR T cells with superantigenic staphylococcal toxins.},
  author={Julie Callahan and Andrew Herman and John W. Kappler and Philippa Marrack},
  journal={Journal of immunology},
  volume={144 7},
The Staphylococcus aureus enterotoxins are known to be potent T cell activators, stimulating cell proliferation and lymphokine production. Two additional S. aureus proteins, exfoliating toxin and toxic shock syndrome toxin, share these properties. Recently these molecules have been termed "super-antigens" because of their ability to bind to class II MHC molecules and thus form ligands that interact with TCR in an unconventional manner. In this paper we show that each toxin stimulates mouse T… CONTINUE READING


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