Stimulation of B-chronic lymphocytic leukemia cells by murine fibroblasts, IL-4, anti-CD40 antibodies, and the soluble CD40 ligand.

@article{Buske1997StimulationOB,
  title={Stimulation of B-chronic lymphocytic leukemia cells by murine fibroblasts, IL-4, anti-CD40 antibodies, and the soluble CD40 ligand.},
  author={Christian Buske and G Gogowski and Karin Schreiber and Margaret Rave-Fr{\"a}nk and Wolfgang Hiddemann and Bernhard Josef W{\"o}rmann},
  journal={Experimental hematology},
  year={1997},
  volume={25 4},
  pages={329-37}
}
Analysis of growth regulation in B-chronic lymphocytic leukemia (B-CLL) is of pivotal importance for understanding the pathophysiology and the development of new therapeutic approaches. We investigated the effect of soluble ligands and the interaction with fibroblasts in an in vitro system developed for the expansion of normal B lymphocytes. A total of 17 peripheral blood and bone marrow samples from patients with untreated B-CLL were analyzed for survival, apoptosis, and bcl-2 protein… CONTINUE READING
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