Stimulation of Anterior Thalamic Nuclei Protects Against Seizures and Neuronal Apoptosis in Hippocampal CA3 Region of Kainic Acid-induced Epileptic Rats.

@article{Meng2016StimulationOA,
  title={Stimulation of Anterior Thalamic Nuclei Protects Against Seizures and Neuronal Apoptosis in Hippocampal CA3 Region of Kainic Acid-induced Epileptic Rats.},
  author={Da-Wei Meng and Huan-guang Liu and An-chao Yang and Kai Zhang and Jianguo Zhang},
  journal={Chinese medical journal},
  year={2016},
  volume={129 8},
  pages={
          960-6
        }
}
BACKGROUND The antiepileptic effect of the anterior thalamic nuclei (ANT) stimulation has been demonstrated; however, its underlying mechanism remains unclear. The aim of this study was to investigate the effect of chronic ANT stimulation on hippocampal neuron loss and apoptosis. METHODS Sixty-four rats were divided into four groups: The control group, the kainic acid (KA) group, the sham-deep brain stimulation (DBS) group, and the DBS group. KA was used to induce epilepsy. Seizure count and… CONTINUE READING

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