Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.

@article{Hagan1997StimulationO5,
  title={Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.},
  author={J. Hagan and P. Slade and L. Gaster and P. Jeffrey and J. Hatcher and D. Middlemiss},
  journal={European journal of pharmacology},
  year={1997},
  volume={331 2-3},
  pages={
          169-74
        }
}
The selective, brain penetrant, 5-HT(1B/D) (formerly 5-HT(1D beta/alpha)) receptor agonist SKF-99101H (3-(2-dimethylaminoethyl)-4-chloro-5-propoxyindole hemifumarate) (30 mg/kg i.p.) causes a dose related fall in rectal temperature in guinea pigs which previous studies have shown to be blocked by the non-selective 5-HT(1B/D) receptor antagonist GR-127935 (N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl) [1,1'biphenyl]-4-carboxamide oxalate). The… Expand
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