Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.

@article{Hagan1997StimulationO5,
  title={Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.},
  author={Jim J. Hagan and Paul Slade and L. M. Gaster and Phillip Jeffrey and Jonathan P. Hatcher and Derek N. Middlemiss},
  journal={European journal of pharmacology},
  year={1997},
  volume={331 2-3},
  pages={
          169-74
        }
}
The effect of serotonin 5HT1B receptor ligands on amphetamine self-administration in rats.
The effect of SB-236057-A, a selective 5-HT1B receptor inverse agonist, on in vivo extracellular 5-HT levels in the freely-moving guinea-pig
TLDR
Data suggest that acute 5- HT1B receptor blockade, by virtue of increased 5-HT release in the dentate gyrus, may provide a rapidly acting antidepressant.
Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists.
TLDR
5-HT1B receptors seem to play an important role in modulating gastric accommodation to a distending stimulus, and an exponential model for pressure-volume curves fits well with the concept of gastric adaptive relaxation.
SB-236057-A: a selective 5-HT1B receptor inverse agonist.
TLDR
It appears that acute 5- HT1B receptor blockade, by virtue of increased 5-HT release in the dentate gyrus, may provide a rapidly acting antidepressant.
...
...

References

SHOWING 1-10 OF 14 REFERENCES
Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig
TLDR
The present data suggest that antagonism of GR46611-induced hypothermia may be useful for assessing the potency and duration of action of centrally-acting 5-HT 1D receptor antagonists in the guinea-pig.
5-HT 1D receptors mediate SKF 99101H-induced hypothermia in the guinea pig
TLDR
The selective, brain penetrant, 5-HT1D receptor agonist SKF 99101H caused a dose-related fall in rectal temperature in guinea pigs which lasted longer than 2 h, and may serve as a useful model for investigation of centrally acting 5- HT 1D receptor antagonists.
SB-216641 and BRL-15572 – compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors
TLDR
Both compounds were partial agonists in these high receptor expression systems, with potencies and selectivities which correlated with their receptor binding affinities, and will be useful pharmacological agents to characterise 5- HT1B and 5-HT1D receptor mediated responses.
Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors
TLDR
In conclusion, SB-216641 behaves as a preferential antagonist at native human 5-HT1B receptors and BRL-15572 as a Preferential antagonists at nativehuman 5- HT1D receptors are clearly useful tools for the differentiation between human5-HT 1B and 5-ht1D receptor in functional studies.
GR127935: a potent and selective 5-HT1D receptor antagonist
The central effect of 5-hydroxytryptamine, gamma-amino-butyric acid and carbachol on thermoregulation in the neonatal guinea pig.
  • I. Komáromi
  • Biology
    Acta physiologica Academiae Scientiarum Hungaricae
  • 1976
TLDR
5-Hydroxytryptamine (5-HT), gamma-amino-butyric acid (GABA) and carbachol were injected into the lateral cerebral ventricle of guinea pigs and produced no immediate change in oxygen consumption, whereas colonic temperature fell rapidly.
A subfamily of 5-HT1D receptor genes.
A proposed new nomenclature for 5-HT receptors.
...
...