Stimulation of ‘irritant’ receptors and afferent C-fibres in the lungs by prostaglandins

@article{Coleridge1976StimulationO,
  title={Stimulation of ‘irritant’ receptors and afferent C-fibres in the lungs by prostaglandins},
  author={Hartley Coleridge and J. C. G. Coleridge and K. H. Ginzel and Dewleen G. Baker and Robert Banzett and Michael A. Morrison},
  journal={Nature},
  year={1976},
  volume={264},
  pages={451-453}
}
THE lungs are among the many organs that generate, release and destroy prostaglandins (PGs)1. It has been suggested that PCs act as ‘local hormones’2, so that prostaglandins E1 and E2, which relax the smooth muscle of bronchi and pulmonary blood vessels in many species, and F2α, which contracts it, may be implicated in normal regulation of airway and pulmonary vascular calibre3. PGF2α has been proposed as a causal factor in asthma4. The bronchoconstrictor effect of PGF2α is reduced by atropine… CONTINUE READING
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