Stimulation in vivo of the secretion of prolactin and growth hormone by beta-endorphin.


Morphine sulfate (MS) and the opioid peptide beta-endorphin beta-LPH-(61-91) stimulate prolactin and growth hormone release in steroid-primed and non-treated male rats when injected intravenously or intracisternally. On a molar basis beta-endorphin is at least 20 times more potent than MS, whereas Met5-enkephalin (beta-LPH-(61-65)) and alpha-endorphin (beta-LPH-(61-76)) are devoid of activity at the dose injected (300 mug). The in vivo stimulatory effects of beta-endorphin on prolactin secretion are reversed by the opiate antagonist naloxone. The absence of in vitro effect of MS and beta-endorphin on prolactin and growth hormone secretion by cultured rat pituitary cells suggest that they have a central nervous system site of action.


Citations per Year

1,678 Citations

Semantic Scholar estimates that this publication has 1,678 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Rivier1977StimulationIV, title={Stimulation in vivo of the secretion of prolactin and growth hormone by beta-endorphin.}, author={Catherine L Rivier and Wylie W. Vale and Nick Ling and Milton Brown and Roger Guillemin}, journal={Endocrinology}, year={1977}, volume={100 1}, pages={238-41} }