Stimulation by toll-like receptors inhibits osteoclast differentiation.

@article{Takami2002StimulationBT,
  title={Stimulation by toll-like receptors inhibits osteoclast differentiation.},
  author={Masamichi Takami and Nacksung Kim and Jaerang Rho and Yongwon Choi},
  journal={Journal of immunology},
  year={2002},
  volume={169 3},
  pages={1516-23}
}
Osteoclasts, the cells capable of resorbing bone, are derived from hemopoietic precursor cells of monocyte-macrophage lineage. The same precursor cells can also give rise to macrophages and dendritic cells, which are essential for proper immune responses to various pathogens. Immune responses to microbial pathogens are often triggered because various microbial components induce the maturation and activation of immunoregulatory cells such as macrophages or dendritic cells by stimulating Toll… CONTINUE READING

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