Stimulation by prostaglandin E2 of glucagon and insulin release from isolated rat pancreas.

@article{Pek1975StimulationBP,
  title={Stimulation by prostaglandin E2 of glucagon and insulin release from isolated rat pancreas.},
  author={Sumer Belbez Pek and Tracy Sock Yin Tai and Allen D. Elster and Fajans},
  journal={Prostaglandins},
  year={1975},
  volume={10 3},
  pages={
          493-502
        }
}
To ascertain whether prostaglandins (PG) may play a role in the secretion of glucagon and in an attempt to elucidate the conflicting observations on the effects of PG on insulin release, the isolated intact rat pancreas was perfused with solutions containing 1.1 x 10(-9) to 1.8 x 10(-5)m PGE2. In the presence of 5.6 mM glucose significant increments in portal venous effluent levels of glucagon and insulin were observed in response to minimal concentrations of 2.8 X 10(-8) and 1.4 X 10(-7) PGE2… CONTINUE READING

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