Stimulation by prostaglandin E2 of alkaline secretion in the rat duodenum: comparative study with hypertonic NaCl.

Abstract

Possible involvement of increased mucosal permeability in the stimulation by prostaglandin E2 (PGE2) of duodenal HCO3- secretion was investigated in rats. PGE2 (0.3, 1 mg/kg, s.c.) dose-dependently increased HCO3- secretion in the duodenum with a significant elevation of transmucosal potential difference (PD); the PD was increased from -4.5 +/- 0.3 mV to… (More)

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@article{Takeuchi1990StimulationBP, title={Stimulation by prostaglandin E2 of alkaline secretion in the rat duodenum: comparative study with hypertonic NaCl.}, author={Kosei Takeuchi and Hiroyuki Niida and Yusuke Takinami and Seiichi Okabe}, journal={Japanese journal of pharmacology}, year={1990}, volume={53 1}, pages={67-74} }