Stimulation by epinephrine of histamine synthesis by rat peritoneal fluid mast cells in vitro.

@article{Rothschild1984StimulationBE,
  title={Stimulation by epinephrine of histamine synthesis by rat peritoneal fluid mast cells in vitro.},
  author={AnthonyJ. Rothschild and Eleni L. T. Gomes},
  journal={Life sciences},
  year={1984},
  volume={35 16},
  pages={
          1645-51
        }
}
In vitro exposure of mast but not of other cells of rat peritoneal fluid to epinephrine leads, within 1 min, to progressing levels of histamine in both fluid and sedimentable phases of the incubates, which present no increase in their free/total histamine ratio. Histamine increase was blocked by alpha-fluoromethyl histidine (alpha FMH), acting after a significant lag period. When compared with controls under the electron microscope, epinephrine-treated mast cells show less electron-dense… CONTINUE READING
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