Stimulation and inhibition of pituitary growth hormone release by angiotensin II in vitro.

@article{Robberecht1988StimulationAI,
  title={Stimulation and inhibition of pituitary growth hormone release by angiotensin II in vitro.},
  author={Wim Robberecht and Carl Denef},
  journal={Endocrinology},
  year={1988},
  volume={122 4},
  pages={1496-504}
}
Rat pituitary cell aggregates cultured in serum-free chemically defined medium, single cells, and hemipituitaries were used in a perifusion system to study the influence of angiotensin II (AII) on GH release. In aggregates the peptide displayed both stimulatory and inhibitory effects on GH release, depending on the hormonal conditions of the culture medium and the age of the animal. When cultured in the absence of glucocorticoid, a modest but statistically significant stimulation was seen in… CONTINUE READING