Stimulation and inhibition of [3H]ryanodine binding to sarcoplasmic reticulum from malignant hyperthermia susceptible pigs.

@article{Mickelson1990StimulationAI,
  title={Stimulation and inhibition of [3H]ryanodine binding to sarcoplasmic reticulum from malignant hyperthermia susceptible pigs.},
  author={James R. Mickelson and Lynn A Litterer and Blake A. Jacobson and Charles Francis Louis},
  journal={Archives of biochemistry and biophysics},
  year={1990},
  volume={278 1},
  pages={251-7}
}
When compared to normal pig sarcoplasmic reticulum (SR), SR from malignant hyperthermia susceptible (MHS) porcine skeletal muscle has been shown to exhibit an increased rate of calcium release, as well as alterations in [3H]ryanodine-binding activity in the presence of microM Ca2+ (Mickelson et al., 1988, J. Biol. Chem. 263, 9310). In the present study, various stimulators (adenine nucleotides and caffeine) and inhibitors (ruthenium red and Mg2+) of the SR calcium release channel were examined… CONTINUE READING
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