Stimulation and antagonism of opioid delta-receptors produce opposite effects on active avoidance conditioning in mice.

@article{Schulteis1988StimulationAA,
  title={Stimulation and antagonism of opioid delta-receptors produce opposite effects on active avoidance conditioning in mice.},
  author={Gery Schulteis and Joe L. Martinez and Victor J. Hruby},
  journal={Behavioral neuroscience},
  year={1988},
  volume={102 5},
  pages={678-86}
}
The effects of opioid delta-receptor activation on conditioning in a one-way active avoidance paradigm were investigated in mice. Peripheral administration of 30 and 100 micrograms/kg of [Leu5]enkephalin (LE) and 11.6 micrograms/kg of [D-Pen2,D-Pen5]enkephalin (DPDPE), a synthetic enkephalin analog with high delta-selectivity, impaired acquisition of avoidance responding. The dose response functions for both peptides were U-shaped. Deficits in responding were also present 24 hours after… CONTINUE READING

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