Stimulating and blocking thyroid-stimulating hormone (TSH) receptor autoantibodies from patients with Graves' disease and autoimmune hypothyroidism have very similar concentration, TSH receptor affinity, and binding sites.

@article{Morgenthaler2007StimulatingAB,
  title={Stimulating and blocking thyroid-stimulating hormone (TSH) receptor autoantibodies from patients with Graves' disease and autoimmune hypothyroidism have very similar concentration, TSH receptor affinity, and binding sites.},
  author={Nils G. Morgenthaler and Su Chin Ho and Waldemar B. Minich},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2007},
  volume={92 3},
  pages={
          1058-65
        }
}
OBJECTIVE The distinct biological properties of TSH receptor (TSH-R) autoantibodies (TRAbs) from patients with Graves' disease (GD) are yet unexplained on the molecular level. Here we compare serum concentration, affinity to the TSH-R, and binding sites on the TSH-R of stimulating (TSAb) and blocking (TBAb) TRAbs. METHODS AND PATIENTS Four-step affinity purification using human recombinant TSH-R was performed with 22 TRAb-positive sera from GD patients (11 with only TSAb and 11 with only TBAb… CONTINUE READING

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