Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface

@article{Dale2002StimulatedPU,
  title={Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface},
  author={George L. Dale and Paul Friese and Peter Batar and Stephen F. Hamilton and Guy L Reed and Kenneth W. Jackson and Kenneth J. Clemetson and Lorenzo Alberio},
  journal={Nature},
  year={2002},
  volume={415},
  pages={175-179}
}
Activated platelets bind numerous adhesive and procoagulant proteins by receptor-mediated processes. Although there is little evidence to suggest that these processes are heterogeneous in platelets, we previously found that platelets co-stimulated with collagen and thrombin express functional α-granule factor V only on a subpopulation of cells. Here we show that these cells, referred to as ‘COAT-platelets’, bind additional α-granule proteins, including fibrinogen, von Willebrand factor… CONTINUE READING
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