Stimulated neovascularization, inflammation resolution and collagen maturation in healing rat cutaneous wounds by a heparan sulfate glycosaminoglycan mimetic, OTR4120

@article{Tong2009StimulatedNI,
  title={Stimulated neovascularization, inflammation resolution and collagen maturation in healing rat cutaneous wounds by a heparan sulfate glycosaminoglycan mimetic, OTR4120},
  author={Miao Tong and Bastiaan Tuk and Ineke M. Hekking and Marcel Vermeij and Denis Barritault and Johan W. van Neck},
  journal={Wound Repair and Regeneration},
  year={2009},
  volume={17}
}
Heparan sulfate glycosaminoglycans (HS‐GAGs) are not only the structural elements of tissue architecture but also regulate the bioavailability and transduction pathways of heparan sulfate‐bound polypeptides released by cells or the extracellular matrix. Heparan sulfate‐bound polypeptides include inflammatory mediators, chemokines, angiogenic factors, morphogens, and growth‐promoting factors that induce cell migration, proliferation, and differentiation in wound healing. OTR4120, a polymer… 
Diabetes-Impaired Wound Healing Is Improved by Matrix Therapy With Heparan Sulfate Glycosaminoglycan Mimetic OTR4120 in Rats
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Natural and synthetic polymers for wounds and burns dressing.
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Heparan sulfate glycosaminoglycan mimetic improves pressure ulcer healing in a rat model of cutaneous ischemia‐reperfusion injury
  • Miao Tong, B. Tuk, J. V. van Neck
  • Medicine, Biology
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2011
TLDR
It is concluded that OTR4120 treatment reduces pressure ulcer formation and potentiates the internal healing bioavailability and long‐term restoration of wounded tissue biomechanical strength was significantly enhanced after OTR 4120 treatment.
Comparative evaluation of the wound-healing potency of recombinant bFGF and ski gene therapy in rats
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Results not only confirm that Ski plays a dual role in promoting healing and reducing scarring but also suggest that Ski yields better treatment effects than bFGF, indicating better potential therapeutic effects in wound repair.
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