Stimulated neovascularization, inflammation resolution and collagen maturation in healing rat cutaneous wounds by a heparan sulfate glycosaminoglycan mimetic, OTR4120
@article{Tong2009StimulatedNI, title={Stimulated neovascularization, inflammation resolution and collagen maturation in healing rat cutaneous wounds by a heparan sulfate glycosaminoglycan mimetic, OTR4120}, author={Miao Tong and Bastiaan Tuk and Ineke M. Hekking and Marcel Vermeij and Denis Barritault and Johan W. van Neck}, journal={Wound Repair and Regeneration}, year={2009}, volume={17} }
Heparan sulfate glycosaminoglycans (HS‐GAGs) are not only the structural elements of tissue architecture but also regulate the bioavailability and transduction pathways of heparan sulfate‐bound polypeptides released by cells or the extracellular matrix. Heparan sulfate‐bound polypeptides include inflammatory mediators, chemokines, angiogenic factors, morphogens, and growth‐promoting factors that induce cell migration, proliferation, and differentiation in wound healing. OTR4120, a polymer…
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