Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi.

@article{Evans2010StimulatedIR,
  title={Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi.},
  author={Scott E Evans and Brenton L. Scott and Cecilia Clement and Derek T. Larson and Dimitrios Kontoyiannis and Russell E Lewis and Paul Rocco Lasala and Jennifer E Pawlik and Johnny W. Peterson and Ashok Kumar Chopra and Gary R. Klimpel and Gabriela Bowden and Magnus H{\"o}{\"o}k and Yi Xu and Michael J. Tuvim and Burton F Dickey},
  journal={American journal of respiratory cell and molecular biology},
  year={2010},
  volume={42 1},
  pages={40-50}
}
Pneumonia is a serious problem worldwide. We recently demonstrated that innate defense mechanisms of the lung are highly inducible against pneumococcal pneumonia. To determine the breadth of protection conferred by stimulation of lung mucosal innate immunity, and to identify cells and signaling pathways activated by this treatment, mice were treated with an aerosolized bacterial lysate, then challenged with lethal doses of bacterial and fungal pathogens. Mice were highly protected against a… CONTINUE READING
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