Stimulated increase in free cytosolic Ca2+ and protein kinase C activity in human cerebrocortical synaptosomes

  title={Stimulated increase in free cytosolic Ca2+ and protein kinase C activity in human cerebrocortical synaptosomes},
  author={M. C. Moe and J. Berg-Johnsen and G. K. R{\o}ste and M. Vinje},
  journal={Brain Research},
  • M. C. Moe, J. Berg-Johnsen, +1 author M. Vinje
  • Published 2002
  • Medicine, Biology
  • Brain Research
  • Protein kinase C (PKC) is an important family of kinases regulated by lipid second messengers and cofactors that interact with cellular membranes. Both Ca(2+)-dependent and -independent isoforms of PKC have been described in rat cerebrocortical presynaptic nerve terminals (synaptosomes). In the present study, synaptosomes were prepared from human cerebral cortex obtained from standard temporal lobe specimens removed due to epilepsy. In order to measure free cytosolic Ca(2+) ([Ca(2+)](i)) and… CONTINUE READING
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