Stimulated human neutrophils damage cardiac sarcoplasmic reticulum function by generation of oxidants.

@article{Kukreja1989StimulatedHN,
  title={Stimulated human neutrophils damage cardiac sarcoplasmic reticulum function by generation of oxidants.},
  author={Rakesh C. Kukreja and Ann Weaver and Michael L. Hess},
  journal={Biochimica et biophysica acta},
  year={1989},
  volume={990 2},
  pages={
          198-205
        }
}
An important aspect of myocardial injury is the role of neutrophils in post-ischemic damage to the heart. Stimulated neutrophils initiate a series of reactions that produce toxic oxidizing agents. Superoxide rapidly dismutases to H2O2 and neutrophils contain myeloperoxidase which catalyzes the oxidation of Cl- by H2O2 to yield hypochlorous acid (HOCl). The highly reactive HOCl combines non-enzymatically with nitrogenous compounds to generate long-lived, non-radical oxidants, monochloramine and… CONTINUE READING

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