Stimulant and depressant properties of sedative-hypnotics in mice selectively bred for differential sensitivity to ethanol

@article{Dudek1984StimulantAD,
  title={Stimulant and depressant properties of sedative-hypnotics in mice selectively bred for differential sensitivity to ethanol},
  author={Bruce C. Dudek and Michael E. Abbott and Tamara J Phillips},
  journal={Psychopharmacology},
  year={1984},
  volume={82},
  pages={46-51}
}
A genetic analysis of sedative-hypnotic response in selectively bred Long-Sleep (LS) and Short-Sleep (SS) mice showed LS mice to be more depressed by acetaldehyde, ethanol (ETOH), and t-butanol, but less sensitive to pentobarbital. Intermediate inheritance was shown by the two reciprocal F1 hybrids for the alcohols, but dominance to the LS genotype occurred for the aldehyde and the barbiturate. At severa subhypnotic doses of ETOH in two experiments, LS mice showed less locomotor stimulation and… CONTINUE READING

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