Stimulant‐induced exocytosis from neuronal somata, dendrites, and newly formed synaptic nerve terminals in chronically decentralized sympathetic ganglia of the rat

  title={Stimulant‐induced exocytosis from neuronal somata, dendrites, and newly formed synaptic nerve terminals in chronically decentralized sympathetic ganglia of the rat},
  author={Zeenat Fatima Zaidi and MargaretR. Matthews},
  journal={Journal of Comparative Neurology},
Loss of preganglionic neurones underlies the autonomic failure of human multiple system atrophy. In rat sympathetic ganglia decentralization leads to new synapse formation. We explored whether these synapses are functional, and whether chronically decentralized neurones respond normally to activation, in terms of exocytosis. Potassium depolarization and cholinergic agonists were applied to freshly excised rat superior cervical sympathetic ganglia, preganglionically denervated with prevented… 

Imaging of evoked dense-core-vesicle exocytosis in hippocampal neurons reveals long latencies and kiss-and-run fusion events

The slow evoked release of neuropeptides could be attributed to very prolonged latencies from stimulation to fusion and transient fusion-pore openings that might limit cargo secretion.

Nerve Fibres Immunoreactive for Calcitonin Gene-Related Peptide and Substance P in the Rat Superior Cervical Sympathetic Ganglion: Distribution, Incidence and Increase with Synapse Formation Following Preganglionic Denervation

It is suggested that activity in such new sensory collateral branches may contribute to the low levels of ganglionic activation observable in the autonomic failure of multiple system atrophy in man.

Postdecentralization plasticity of voltage‐gated K+ currents in glandular sympathetic neurons in rats

It is suggested that the upregulation of voltage‐gated time‐dependently‐inactivated K+ currents and their faster recovery from inactivation serve to restrain the activity of glandular sympathetic neurons after decentralization.

Synaptic and Extrasynaptic Secretion of Serotonin

The evidence of synaptic and extrasynaptic release of serotonin and the mechanisms underlying each secretion mode are reviewed by combining evidence from vertebrates and invertebrates, with particular emphasis on somatic secretion of serotonin by central neurons.

Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system

We review the evidence of exocytosis from extrasynaptic sites in the soma, dendrites, and axonal varicosities of central and peripheral neurons of vertebrates and invertebrates, with emphasis on

Time-course of post-denervation changes in calcitonin gene-related peptide and substance P immunoreactive nerve fibres in superior cervical ganglion in rat

It is indicated that many if not all fibres of the networks arise, in two phases, by sprouting from small bundles of similarly immunoreactive nerve fibres which traverse the normal ganglion, entering or leaving it at many points.

A comparison of the changes in the non-neuronal cell populations of the superior cervical ganglia following decentralization and axotomy.

Future studies must address what role(s) infiltrating and/or resident macrophages play in regions of decentralized and axotomized neurons and, if both are involved, whether they play distinct roles.

Somatic Exocytosis of Serotonin Mediated by L‐Type Calcium Channels in Cultured Leech Neurones

The results suggest that somatic exocytosis by neurones shares common mechanisms with excitable endocrine cells and was quantified by use of the fluorescent dye FM 1–43.



Substance P-immunoreactive peripheral branches of sensory neurons innervate guinea pig sympathetic neurons.

  • M. MatthewsA. Cuello
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1982
It is proposed that the SPI synapses in the IMG arise from collateral branches of these sensory peripheral processes, which implies a novel role for these processes, in forming intraganglionically in the prevertebral ganglia synapses which may take part in the reflex control of the viscera, independently of the central nervous system.

Lack of nicotinic supersensitivity in frog sympathetic neurones following denervation.

It is concluded that denervation does not cause frog sympathetic neurones to become supersensitive to ACh, and the apparent increase in nicotinic ACh sensitivity observed using extracellular recording from whole ganglia is due not to a change in the number or distribution of ACh receptors, but to a decrease in cholinesterase activity.

The distribution of acetylcholine receptors in chick ciliary ganglion neurons following disruption of ganglionic connections

  • M. JacobD. K. Berg
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1988
The results show that the operations do not qualitatively change the subcellular localization of AChRs, but they do alter the levels relative to control ganglia.