Stilbene analogs as inducers of apolipoprotein-I transcription.

@article{Hansen2010StilbeneAA,
  title={Stilbene analogs as inducers of apolipoprotein-I transcription.},
  author={Henrik C. Hansen and Fabrizio S Chiacchia and Reena J Patel and Norman C. W. Wong and Vladimir Khlebnikov and Renata Jankowska and Kalpesh Patel and Mamatha M. Reddy},
  journal={European journal of medicinal chemistry},
  year={2010},
  volume={45 5},
  pages={2018-23}
}
Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more potent than Resveratrol were identified. trans-4,4'-dihydroxy-2-methoxystilbene was the most potent (4.6x more potent than Resveratrol). These… CONTINUE READING