Stiffening of human mesenchymal stem cell spheroid microenvironments induced by incorporation of gelatin microparticles.

@article{Baraniak2012StiffeningOH,
  title={Stiffening of human mesenchymal stem cell spheroid microenvironments induced by incorporation of gelatin microparticles.},
  author={Priya R. Baraniak and Marissa T. Cooke and Rabbia Saeed and Melissa A. Kinney and Krista M. Fridley and Todd C. McDevitt},
  journal={Journal of the mechanical behavior of biomedical materials},
  year={2012},
  volume={11},
  pages={63-71}
}
Culturing multipotent adult mesenchymal stem cells as 3D aggregates augments their differentiation potential and paracrine activity. One caveat of stem cell spheroids, though, can be the limited diffusional transport barriers posed by the inherent 3D structure of the multicellular aggregates. In order to circumvent such limitations, polymeric microparticles have been incorporated into stem cell aggregates as a means to locally control the biochemical and physical properties of the 3D… CONTINUE READING
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