Stiff-person syndrome: insights into a complex autoimmune disorder

@article{BaizabalCarvallo2014StiffpersonSI,
  title={Stiff-person syndrome: insights into a complex autoimmune disorder},
  author={Jos{\'e} Fidel Baizabal-Carvallo and Joseph Jankovic},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={2014},
  volume={86},
  pages={840 - 848}
}
Stiff-person syndrome (SPS) is characterised by progressive rigidity and muscle spasms affecting the axial and limb muscles. Since its initial description in 1956, marked progress has been made in the clinical characterisation, understanding of pathogenesis and therapy of this disorder. SPS can be classified according to the clinical presentation into classic SPS and SPS variants: focal or segmental-SPS, jerking-SPS and progressive encephalomyelitis with rigidity and myoclonus. Most patients… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Closer study of the mysterious stiff-person syndrome should enhance the understanding of this disease itself, and autoimmunity in general. Expand
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TLDR
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TLDR
Rituximab is an important treatment strategy in SPS and the persistence of anti-GAD antibody positivity even with clinical remission remains to be elucidated. Expand
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TLDR
The results of rituximab treatment in a patient with SPS associated with a thymoma, diabetes mellitus, autoimmune thyroiditis and the presence of anti-GAD and anti-amphiphysin autoantibodies are reported. Expand
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