Stiff-person syndrome: insights into a complex autoimmune disorder.

  title={Stiff-person syndrome: insights into a complex autoimmune disorder.},
  author={Jos{\'e} Fidel Baizabal-Carvallo and Joseph Jankovic},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  volume={86 8},
Stiff-person syndrome (SPS) is characterised by progressive rigidity and muscle spasms affecting the axial and limb muscles. Since its initial description in 1956, marked progress has been made in the clinical characterisation, understanding of pathogenesis and therapy of this disorder. SPS can be classified according to the clinical presentation into classic SPS and SPS variants: focal or segmental-SPS, jerking-SPS and progressive encephalomyelitis with rigidity and myoclonus. Most patients… CONTINUE READING
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