Sticky socks: Helicobacter pylori VacA takes shape.

  title={Sticky socks: Helicobacter pylori VacA takes shape.},
  author={Xaver Sewald and Wolfgang Fischer and Rainer Haas},
  journal={Trends in microbiology},
  volume={16 3},
Several receptors have been described for the Helicobacter pylori vacuolating toxin VacA, which exerts different effects on epithelial cells and on immune cells. The crystal structure of the putative receptor-binding domain of VacA (p55) has now been solved. It consists of a parallel beta-helix with a C-terminal globular domain. A comparison between allelic variants of p55 and docking of the p55 domain into the quaternary structure, as shown by electron microscopy, revealed structural features… CONTINUE READING