Stevens–Johnson syndrome and toxic epidermal necrolysis due to anticonvulsants share certain clinical and laboratory features with drug‐induced hypersensitivity syndrome, despite differences in cutaneous presentations

@article{Teraki2010StevensJohnsonSA,
  title={Stevens–Johnson syndrome and toxic epidermal necrolysis due to anticonvulsants share certain clinical and laboratory features with drug‐induced hypersensitivity syndrome, despite differences in cutaneous presentations},
  author={Yuichi Teraki and Makiko Shibuya and Seiichi Izaki},
  journal={Clinical and Experimental Dermatology},
  year={2010},
  volume={35}
}
Background.  Drug‐induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is characterized by late disease onset, fever, rash, hepatic dysfunction, haematological abnormalities, lymphadenopathy and often, human herpesvirus (HHV) reactivation. The diagnosis of DIHS is based on the combined presence of these findings. Anticonvulsants are a major cause of DIHS and may also cause Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN… 
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A case of drug reaction with eosinophilia and systemic symptoms induced by ethambutol with early features resembling Stevens-Johnson syndrome.
TLDR
A case of ethambutol-induced DRESS with early features resembling SJS is reported, and clinical similarities between them can cause confusion in diagnosis, leading to delays in proper management.
Successful Treatment for Toxic Epidermal Necrolysis/Drug-Induced Hypersensitivity Syndrome Overlap with Corticosteroids, Intravenous Immunoglobulins and Plasma Exchange
TLDR
A rare case of DIHS with skin manifestation of TEN successfully treated with PE is presented, with atypical target lesions with blister and erosions, which rapidly extended over the trunk and limb.
Histopathology of Severe Drug Eruptions
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    Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions
  • 2018
In diagnosing cutaneous adverse drug reactions, the histopathological findings must be examined, and those findings provide insight into the pathomechanisms of these disorders. The characteristic…
Cicatrizing Conjunctivitis in a Patient Diagnosed With Drug Reaction With Eosinophilia and Systemic Symptoms/Drug-Induced Hypersensitivity Syndrome but With Features of Stevens–Johnson Syndrome
TLDR
The development of severe ocular surface mucosal inflammation and denudation with cicatrizing sequelae in a patient carrying a diagnosis of DRESS/DIHS has diagnostic and therapeutic implications for the ophthalmologist.
Severe Cutaneous Adverse Reactions to Antiepileptic Drugs: A Nationwide Registry-Based Study in Korea
TLDR
The results suggest that the clinical characteristics and clinical courses of AED-induced SCARs might vary according to the individual AEDs, and Carbamazepine was associated with reduced hospitalization, but thrombocytopenia was a risk factor for prolonged hospitalization.
Clinical course of drug‐induced hypersensitivity syndrome treated without systemic corticosteroids
TLDR
Drug‐induced hypersensitivity syndrome is a severe reaction to drugs which characteristically occurs after a long latency period, and the natural clinical course is not clear.
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  • S. Kardaun
  • Medicine
    Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions
  • 2018
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a delayed, potentially life-threatening, hypersensitivity reaction characterized by a widespread, long-lasting skin eruption, fever,…
Clinical Features and Prognostic Factors in Severe Cutaneous Drug Reactions
TLDR
Clinical features of SCARs in a tertiary hospital in Korea were similar to those reported previously, and thrombocytopenia for SJS/TEN and leukocytosis at presentation for DRESS may be useful prognostic markers for prolonged hospitalization.
Toxic Epidermal Necrolysis with Prominent Facial Pustules: A Case with Reactivation of Human Herpesvirus 7
TLDR
A 37-year-old Japanese man presented with confluent erythemas and progressive erosive lesions on the almost entire body including the oral mucosa and genitalia and was diagnosed as having toxic epidermal necrolysis with prominent facial pustules and treated by methylprednisolone pulse therapy, which resulted in a good response.
New Insights into Drug Reaction with Eosinophilia and Systemic Symptoms Pathophysiology
TLDR
The key features of this reaction are eosinophil involvement, the role of the culprit drug, and virus reactivation that trigger an inappropriate systemic immune response in DRESS patients are described.
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References

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TLDR
It makes more sense for patients with SJS/TEN to be classified as such and not be lumped together under the misleading label of DRESS syndrome.
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TLDR
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TLDR
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TLDR
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TLDR
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